Review symptoms and risk factors
Perform a physical examination
Order blood tests, including liver function tests and bilirubin
Check tumor markers such as CA 19-9
Perform imaging tests such as abdominal ultrasound
Perform contrast-enhanced CT scan of the pancreas
Perform MRI or MRCP if needed
Use endoscopic ultrasound for closer evaluation
Obtain a biopsy to confirm the diagnosis
Use ERCP if bile duct evaluation or stenting is needed
Stage the cancer with additional imaging if confirmed