Wash the bites with soap and water
Apply a cold compress for 10 to 15 minutes
Use calamine lotion or anti-itch cream
Apply 1% hydrocortisone cream
Take an oral antihistamine if itching is severe
Avoid scratching the bites
Keep the skin clean and dry
Trim fingernails to reduce skin damage from scratching
Seek medical care if there is swelling, pus, fever, or signs of infection
Eliminate the bed bugs to prevent new bites