Use the Rocket Launcher or Super Shotgun at close range
Stay above it and attack from the air when possible
Focus fire on the eye to deal the most damage
Destroy the tumors on its body as soon as they appear
Keep moving to avoid its slam and projectile attacks
Use explosive weapons to clear its weak points quickly
Save high-damage bursts for when it is exposed
Maintain distance until you have a clear opening
Use cover to break line of sight and recover safely
If available, use the Railcannon for heavy burst damage