Get tested and confirm the diagnosis with a healthcare professional
Use antibiotics prescribed by a clinician, usually penicillin
Treat based on the stage of syphilis
Early syphilis is commonly treated with a single injection of benzathine penicillin G
Late latent syphilis and unknown-duration syphilis are commonly treated with three weekly injections of benzathine penicillin G
Neurosyphilis and ocular syphilis are commonly treated with intravenous penicillin G
Use doxycycline or other alternatives only if penicillin cannot be used and under medical supervision
Inform recent sexual partners so they can be tested and treated
Avoid sexual contact until treatment is completed and a clinician says it is safe
Get follow-up blood tests to confirm the infection is responding to treatment
Get tested for other sexually transmitted infections, including HIV
Seek urgent care for neurologic, vision, hearing, or severe symptoms