See a doctor experienced in connective tissue disorders, such as a geneticist, rheumatologist, or knowledgeable primary care clinician
Review personal and family medical history for hypermobility, frequent dislocations, easy bruising, stretchy skin, poor wound healing, chronic pain, or vascular events
Perform a physical examination using the Beighton score to assess joint hypermobility
Assess for other clinical features associated with Ehlers-Danlos syndrome, depending on subtype
Rule out other conditions that can cause similar symptoms
Consider genetic testing when indicated, especially for subtypes with known gene associations
Evaluate for complications such as heart, blood vessel, skin, and joint problems
Use established diagnostic criteria for the specific Ehlers-Danlos syndrome subtype
Confirm the diagnosis with a specialist familiar with Ehlers-Danlos syndrome
Seek urgent evaluation if there is chest pain, sudden severe pain, fainting, or signs of vascular complications