Strip the bed and remove all bedding
Vacuum the mattress surface
Blot fresh stains with a clean dry cloth
Mix mild dish soap with cold water
Dampen a cloth with the solution
Blot the stain gently
Use a clean damp cloth to remove residue
Sprinkle baking soda over the area
Let it sit for several hours
Vacuum the baking soda off
For urine stains, use equal parts white vinegar and water
For sweat or odor stains, use baking soda and water
For blood stains, use cold water only
For grease stains, apply a small amount of cornstarch
For mold or mildew, use vinegar and dry the mattress thoroughly
Avoid soaking the mattress
Let the mattress air dry completely
Use a fan or open windows to speed drying
Repeat if needed
Use a mattress protector to prevent future stains