Strip the bedding and vacuum the mattress
Blot fresh stains with a clean dry cloth
Mix mild dish soap with cold water
Dab the stain with the solution using a clean cloth
Blot with a dry cloth to lift moisture
Sprinkle baking soda over the area
Let it sit for several hours
Vacuum up the baking soda
For urine stains, use equal parts white vinegar and water
For sweat or odor stains, use baking soda and a little hydrogen peroxide
For blood stains, use cold water only
For tough stains, use a small amount of enzyme cleaner
Repeat as needed until the stain fades
Let the mattress air-dry completely
Use a fan or open windows to speed drying
Avoid soaking the mattress
Avoid hot water on protein-based stains
Test any cleaner on a small hidden area first