See a doctor if you have persistent symptoms such as fatigue, joint pain, rash, fever, dry eyes, dry mouth, muscle weakness, or unexplained weight changes
Review your personal and family history of autoimmune disease with a clinician
Get a physical examination focused on affected organs and symptoms
Ask for blood tests such as ANA, CBC, ESR, CRP, and metabolic panel
Ask for disease-specific antibody tests if symptoms suggest a particular autoimmune condition
Check thyroid function tests if you have symptoms of thyroid disease
Check blood sugar or diabetes-related tests if type 1 diabetes is suspected
Provide a urine sample if kidney involvement is suspected
Ask about imaging tests if joints, lungs, or other organs may be involved
Consider referral to a rheumatologist, endocrinologist, gastroenterologist, or other specialist
Keep a symptom diary with timing, triggers, and severity
Seek urgent care for chest pain, trouble breathing, severe weakness, confusion, or sudden swelling