Shut down the computer
Unplug the power cable
Disconnect all peripherals
Remove the battery if applicable
Use compressed air to blow out dust
Clean vents, fans, and ports
Wipe the exterior with a microfiber cloth
Dampen the cloth slightly with water or isopropyl alcohol
Clean the keyboard with compressed air and a soft brush
Wipe the screen with a microfiber cloth
Use a screen-safe cleaner if needed
Clean the mouse and other accessories
Reconnect everything after it is completely dry
Power on the computer