Preheat the oven to 400°F
Line a baking sheet or baking dish with parchment paper or lightly grease it
Pat the tilapia fillets dry with paper towels
Place the fillets on the prepared baking sheet
Brush or drizzle the fillets with olive oil or melted butter
Season with salt, black pepper, garlic powder, and paprika
Add lemon juice or lemon slices if desired
Bake for 10 to 15 minutes
Check that the fish flakes easily with a fork and reaches 145°F internally
Remove from the oven and serve immediately