Let wrinklers stay active while you are actively farming cookies
Pop wrinklers when you want to collect their stored cookies
Keep wrinklers alive longer if you want more total return
Pop wrinklers before ascending if you want to bank the cookies
Use Elder Covenant or related effects only if you want to reduce their impact
Prioritize popping shiny wrinklers first
Refill wrinklers after popping by waiting for them to respawn
Combine wrinklers with golden cookie boosts for better gains
Avoid popping them too early if your goal is maximum profit
Check wrinklers before long idle sessions to plan your collection timing