How to Make a Buffer?

Choose the buffer system you need

Select a weak acid and its conjugate base, or a weak base and its conjugate acid

Decide the target pH

Calculate the required acid-to-base ratio using the Henderson-Hasselbalch equation

Measure the needed amounts of buffer components

Dissolve the components in distilled water

Adjust the pH with small amounts of acid or base if needed

Bring the solution to the final desired volume

Mix thoroughly

Verify the pH with a calibrated pH meter

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