Pat salmon fillets dry
Mix paprika, garlic powder, onion powder, cayenne, thyme, oregano, salt, and black pepper
Brush salmon lightly with melted butter or oil
Coat salmon evenly with the spice mixture
Heat a cast-iron skillet over medium-high to high heat
Add a small amount of oil to the skillet
Place salmon skin-side down if using skin-on fillets
Cook for 3 to 4 minutes without moving
Flip and cook for 2 to 4 minutes more until cooked through
Remove from heat and rest briefly
Serve immediately with lemon wedges if desired