Fullness or pain in the upper left abdomen
Pain that may spread to the left shoulder
Feeling full after eating only a small amount
Abdominal bloating or discomfort
Tenderness when pressing the upper left abdomen
Fatigue
Frequent infections
Easy bruising or bleeding
Unexplained weight loss
Fever
A doctor feeling an enlarged spleen during a physical exam
Confirmation with imaging tests such as ultrasound, CT scan, or MRI