Do not stop Cymbalta (duloxetine) suddenly
Ask your prescriber for a taper plan before changing the dose
Common taper step: 60 mg daily to 30 mg daily for 1 to 2 weeks
If needed, continue with 20 mg daily for 1 to 2 weeks
Some people need slower reductions, such as every 2 to 4 weeks
If withdrawal symptoms occur, go back to the last tolerated dose and taper more slowly
Do not open, crush, or split delayed-release capsules unless your prescriber or pharmacist specifically instructs you to
Ask about available lower-dose capsules or a pharmacy-compounded option if needed
Monitor for dizziness, nausea, headache, irritability, anxiety, insomnia, or “brain zaps”
Contact your prescriber promptly if symptoms are severe or persistent
Seek urgent help if you have suicidal thoughts, severe mood changes, or signs of serotonin syndrome