Start treatment as soon as you feel tingling, itching, or burning
Use an OTC antiviral cream (docosanol 10%) as directed on the label
Consider OTC antiviral ointment (acyclovir or penciclovir) if available in your area and as directed
Take an oral prescription antiviral if symptoms are severe, frequent, or you’re at higher risk (acyclovir, valacyclovir, or famciclovir) and start within 24–48 hours
Apply a cold compress for 5–10 minutes at a time, several times a day to reduce pain and swelling
Use OTC pain relief (ibuprofen or acetaminophen) as directed
Apply OTC numbing gels/creams (benzocaine or lidocaine) sparingly and as directed
Keep the sore clean and avoid picking or popping blisters
Wash hands often and avoid touching your eyes after touching the affected area
Avoid kissing and oral sex until the sore fully heals
Avoid sharing lip balm, utensils, drinks, razors, towels, or cigarettes
Cover the sore with a hydrocolloid patch or antiviral dressing if available to reduce contact and irritation
Keep the area moisturized with a bland barrier (petrolatum) to prevent cracking
Avoid triggers such as sun exposure; use SPF lip balm and wear lip protection
Use separate products (no re-dipping applicators) to prevent re-contamination
Seek medical care urgently if you have eye pain/redness, vision changes, fever, spreading redness, severe swelling, or you’re immunocompromised
Contact a clinician if it lasts longer than 10–14 days, keeps recurring often, or you have frequent outbreaks