Apply an OTC antiviral cream with docosanol at the first sign of tingling
Use a prescription antiviral if you have one, such as acyclovir, valacyclovir, or famciclovir
Start treatment as early as possible for best results
Apply a cold compress for 10 to 15 minutes at a time
Keep the area clean and dry
Use petroleum jelly or a lip balm to prevent cracking
Take ibuprofen or acetaminophen for pain or discomfort
Avoid picking, squeezing, or peeling the blister
Avoid kissing, oral sex, and sharing drinks, utensils, towels, or lip products
Wash your hands after touching your face or applying treatment
Avoid acidic, salty, or spicy foods if the blister is on your lips
Get enough rest and stay hydrated
See a healthcare professional if outbreaks are frequent, severe, or not healing
Seek urgent care if you have eye symptoms, a weakened immune system, or a widespread rash