Blot up any fresh urine immediately with paper towels or a clean cloth
Remove and wash any cushion covers if they are machine washable
Mix an enzymatic pet urine cleaner according to the label directions
Test the cleaner on a hidden spot of the couch first
Saturate the affected area with the enzymatic cleaner so it reaches the urine in the fabric and padding
Let the cleaner sit for the full recommended time
Blot the area again with clean towels
Repeat the enzymatic treatment if the smell remains
Sprinkle baking soda over the dry area after cleaning
Let the baking soda sit for several hours or overnight
Vacuum up the baking soda thoroughly
Place fans near the couch to speed drying
Keep pets off the couch until it is completely dry
If the odor persists, have the couch professionally cleaned
Avoid using ammonia-based cleaners
Avoid steam cleaning before the urine odor is fully removed
Use a waterproof couch cover or pet protector after cleaning