Wash your hands
Clean the blister and surrounding skin with mild soap and water
Do not pop the blister if possible
Cover it with a blister bandage or nonstick sterile dressing
Use padding or moleskin to reduce pressure and friction
Keep the area dry and change the dressing daily or if it gets wet or dirty
Wear roomy, comfortable shoes and moisture-wicking socks
Rest the foot and avoid activities that rub the blister
If the blister opens, gently wash it, leave the skin flap in place, apply antibiotic ointment if advised, and re-cover it
Watch for signs of infection such as increasing redness, warmth, swelling, pus, or fever
Seek medical care if the blister is very large, very painful, infected, caused by a burn or chemical, or if you have diabetes or poor circulation