Confirm the diagnosis with a urea breath test, stool antigen test, or endoscopy biopsy
Take a prescribed combination of antibiotics plus a proton pump inhibitor
Common first-line options include bismuth quadruple therapy, concomitant therapy, or other guideline-based regimens
Take all medicines exactly as prescribed for the full treatment course
Avoid alcohol if advised by your clinician during treatment
Avoid NSAIDs if they worsen symptoms or if your clinician recommends it
Use a proton pump inhibitor or acid-reducing medicine as directed for symptom relief
Follow up with your clinician after treatment
Repeat testing to confirm eradication at least 4 weeks after antibiotics and after stopping proton pump inhibitors for the recommended period
Seek urgent care for black stools, vomiting blood, severe abdominal pain, fainting, or trouble swallowing
Treat household members or close contacts only if your clinician recommends testing and treatment