Blot up as much urine as possible with clean paper towels or a dry cloth
Remove bedding and wash it separately
Mix equal parts white vinegar and water in a spray bottle
Lightly spray the stained area without soaking the mattress
Blot again with a clean cloth
Sprinkle baking soda over the damp area
Let it sit until completely dry
Vacuum up the baking soda
If the stain remains, apply a small amount of mild dish soap mixed with water
Blot the area with a clean damp cloth to remove soap residue
Repeat as needed until the stain fades
Let the mattress air dry fully
Use a fan or open windows to speed drying
For odors, sprinkle baking soda again and vacuum after several hours
Use an enzyme cleaner for pet or old urine stains
Avoid using too much water
Avoid bleach or harsh chemicals
Use a mattress protector to prevent future stains