Preheat the oven to 350°F
Grease a loaf pan or line a baking sheet with parchment paper
In a large bowl, combine 2 pounds ground beef, 1 cup breadcrumbs, 1 small chopped onion, 2 eggs, 1/2 cup milk, 2 tablespoons ketchup, 1 tablespoon Worcestershire sauce, 1 teaspoon salt, 1/2 teaspoon black pepper, and 1 teaspoon garlic powder
Mix until just combined
Shape the mixture into a loaf and place it in the prepared pan or on the baking sheet
In a small bowl, mix 1/2 cup ketchup, 2 tablespoons brown sugar, and 1 tablespoon mustard
Spread the glaze over the top of the meatloaf
Bake for 55 to 65 minutes
Check that the internal temperature reaches 160°F
Let the meatloaf rest for 10 minutes
Slice and serve