See a doctor, ideally a geneticist, rheumatologist, or cardiologist familiar with EDS
Review personal and family history of joint hypermobility, dislocations, skin findings, and vascular events
Perform a physical exam using the Beighton score for joint hypermobility
Assess for skin hyperextensibility, easy bruising, abnormal scarring, and tissue fragility
Evaluate for recurrent joint dislocations, chronic pain, and joint instability
Check for signs of vascular, cardiac, eye, or organ involvement
Rule out other conditions that can mimic EDS
Consider genetic testing for EDS subtypes where a known gene is available
Use echocardiography if heart or blood vessel involvement is suspected
Use imaging or specialist evaluation for affected joints, vessels, or organs when needed
Confirm the specific EDS subtype based on clinical criteria and test results
Seek urgent medical care if there is sudden severe pain, chest pain, fainting, or signs of internal bleeding