Blot up as much urine as possible with clean paper towels or a dry cloth
Remove bedding and wash it separately
Mix equal parts white vinegar and water in a spray bottle
Lightly spray the stained area
Blot again with a clean cloth
Sprinkle baking soda over the damp area
Let it sit until completely dry
Vacuum up the baking soda
If needed, apply an enzyme cleaner made for urine stains
Follow the product instructions and let it dry fully
Repeat the process if the stain or odor remains
Use a fan or open windows to speed drying
Avoid soaking the mattress
Place a waterproof mattress protector on the mattress after it is clean and dry