Preheat the oven to 400°F
Pat catfish fillets dry
Line a baking sheet with parchment paper or lightly grease it
Season the catfish with salt, black pepper, garlic powder, and paprika
Brush or drizzle the fillets with melted butter or olive oil
Place the fillets on the baking sheet in a single layer
Bake for 12 to 15 minutes, depending on thickness
Check that the fish flakes easily with a fork and reaches 145°F internally
Remove from the oven
Serve immediately with lemon wedges if desired