Select the cell where you want the result
Type `=A1-B1`
Press Enter
Replace `A1` and `B1` with the cells you want to subtract
To subtract more than two cells, use `=A1-B1-C1`
To subtract a number directly, use `=A1-5`
To subtract the same value from multiple cells, drag the fill handle down or across
To subtract with parentheses, use formulas like `=(A1-B1)-C1`