Strip the bedding and vacuum the mattress surface
Blot the stain with a clean, dry cloth
Mix mild dish soap with cold water
Dampen a cloth with the solution and blot the stain
Avoid soaking the mattress
Blot with a clean damp cloth to remove soap residue
Sprinkle baking soda over the area
Let it sit until dry
Vacuum the baking soda off the mattress
For urine stains, use equal parts white vinegar and water
For blood stains, use cold water only
For sweat or odor stains, use a baking soda paste
For stubborn stains, use an enzyme cleaner made for fabrics
Repeat as needed until the stain lifts
Let the mattress air dry completely before remaking the bed