See a healthcare professional for an evaluation of symptoms and medical history
Get a physical exam to check for signs such as rash, joint swelling, mouth ulcers, or hair loss
Have blood tests for antinuclear antibodies (ANA)
If ANA is positive, have additional blood tests such as anti-dsDNA, anti-Smith, anti-Ro/SSA, and anti-La/SSB antibodies
Get blood tests for inflammation and organ involvement, including CBC, ESR, CRP, kidney function, and liver function
Have urine tests to check for protein or blood in the urine
Test complement levels such as C3 and C4
Consider antiphospholipid antibody testing if blood clots, miscarriages, or related symptoms are present
Get skin or kidney biopsy if needed to confirm lupus-related tissue involvement
Review results with a rheumatologist for diagnosis based on symptoms, exam findings, and test results