Wash your hands before touching the blister
Clean the area gently with soap and water
Leave small, unbroken blisters intact
Do not pop the blister unless necessary
If the blister is large, painful, or likely to burst, drain it carefully with a sterilized needle
Keep the blister roof in place after draining
Apply antibiotic ointment if the skin is open
Cover the blister with a clean, nonstick bandage
Change the bandage daily or when it becomes wet or dirty
Reduce pressure and friction on the area
Wear properly fitting shoes and socks
Use moleskin or padding to protect the blister
Keep the area dry and clean
Avoid picking at the blister or peeling skin
Watch for signs of infection such as redness, warmth, pus, or worsening pain
Seek medical care if the blister is infected, very large, caused by burns, or does not heal
Get medical help if you have diabetes, poor circulation, or a weakened immune system