Pat tilapia fillets dry with paper towels
Season both sides with salt, black pepper, garlic powder, and paprika
Heat oil or butter in a skillet over medium heat
Place tilapia in the skillet
Cook for 3 to 4 minutes on the first side
Flip carefully
Cook for 2 to 4 minutes on the second side until the fish flakes easily
Remove from heat
Serve immediately with lemon juice or your preferred sides