Preheat the oven to 450°F
Pat the eye of round roast dry
Rub the roast with salt, pepper, and any desired seasonings
Place the roast on a rack in a roasting pan
Roast for 15 minutes at 450°F
Reduce the oven temperature to 325°F
Continue roasting until the internal temperature reaches 125°F to 130°F for medium-rare or 135°F to 140°F for medium
Remove the roast from the oven
Tent loosely with foil
Let rest for 15 to 20 minutes
Slice thinly against the grain