Symptoms after eating gluten, such as bloating, diarrhea, constipation, abdominal pain, nausea, or vomiting
Unexplained weight loss
Fatigue or weakness
Iron-deficiency anemia or other nutrient deficiencies
Frequent mouth ulcers
Skin rash with itchy blisters, especially on elbows, knees, buttocks, or scalp
Bone or joint pain
Headaches or migraines
Numbness or tingling in hands or feet
Delayed growth or puberty in children
Infertility or recurrent miscarriage
Family history of celiac disease
Type 1 diabetes, autoimmune thyroid disease, or other autoimmune conditions
Positive blood tests for celiac disease, including tTG-IgA, EMA-IgA, or DGP tests
Low total IgA or need for IgG-based celiac tests if IgA deficient
Confirmation with an upper endoscopy and small-bowel biopsy
Continuing to eat gluten before testing, since stopping gluten can cause false-negative results